Sometimes designers are concerned that their images appear less saturated in CMYK mode. Part of that has to do with the fact that your monitor operates in RGB mode, whereas most color files are printed in CMYK. Another reason is simply because there is less information in each of the four ink channels. Most of the time, your prepress professionals are able to "pump up" or "pull back" colors on press to their original saturation. If it is absolutely imperative that a color match perfectly to a prior mockup that your client has seen and signed off on, for instance, talk to your printer about possibly adding in a spot color (a special ink mix) to attain that perfect color. This is a very common practice, and printers are usually very eager to work with you on attaining exact color.
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